The PRIMAGE project developed methods of computational analysis of medical images applied to childhood cancer. PRIMAGE proposes a cloud-based platform to support decision making in the clinical management of malignant solid tumors, offering predictive tools to assist diagnosis, prognosis, therapies choice and treatment follow-up, based on the use of novel imaging biomarkers, in-silico tumor growth simulation, advanced visualization of predictions with weighted confidence scores and machine-learning based translation of this knowledge into predictors for the most relevant, disease-specific, Clinical End Points.